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The, mechanoBiology Laboratory is dedicated to pursue research in areas of fibroblast mechanobiology, soft-tissue wound healing, functional tissue engineering, and biological applications of microfabrication and sensor technologies.
These researchers work collaboratively to take science from theory to life-changing solutions.
This proposals educational and outreach plan aims to maximize the power of computations to enhance learning of organic chemistry concepts and to facilitate synthetic organic chemistry research.This work is dedicated to the ongoing efforts of the theoretical chemistry community to develop a new generation of accurate force fields based on data from high-level electronic structure calculations and to develop faster electronic structure methods for testing and designing force fields as well.Peng Liu has been selected to receive a National Science Foundation career award based upon his proposal, entitled "Computational Studies of Transition-Metal-Catalyzed Reactions in Organic Synthesis.".Professor Lius team will develop virtual reality (VR) software and educational materials to visualize three-dimensional molecular structures and reaction mechanism videos in an interactive and immersive environment.An important goal of molecular nanotechnology is to manipulate single molecules in well-defined chemical environments.Molecular Therapeutics Laboratory, bing Wang, MD, PhD, director.Nature Communications, co-authored by Giannis Mpourmpakis, and PhD candidate Michael Taylor, offers a possible way to unravel these mysteries, with the help of computer simulations.The fact that unassigned stem cells live within adults is a relatively recent and revolutionary discovery.Another area of stem cell research explores ways to speed recovery from muscle injuries by blocking the formation of scar tissue, which typically slows the healing process.However, the details of how protons move in water have remained elusive, and an enhanced understanding of the nature of this process is needed to improve the technologies that depend on proton transfer.The research team actively studies the cellular and molecular mechanisms of tendinopathy, a prevalent tendon disorder that affects millions of people in occupational and athletic settings.
MechanoBiology Laboratory, james H-C Wang, PhD, director.

Based on the knowledge and experience with viral vector development and gene therapy, the laboratory has been also actively engaged in multiple applications of different viral vectors for gene and cell therapies through collaboration with many laboratories internal and external of the University of Pittsburgh.
The goal of this research is to reveal the fundamental reactivity rules of common organometallic intermediates in these transformations and to develop new models to interpret ligand effects on reactivity and selectivity.
Regeneration of muscle, cartilage, nerves and other tissues are all areas of exploration.